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In the presence of the appropriate migratory signals the leukocyte will migrate across the endothelium into tissue, where it follows a hierarchy of chemotactic signals toward the focus of inflammation
V., Patel, S

During hyperphosphorylation, tau protein dissociates from the microtubule, resulting in the spread of unbound microtubules and progressive accumulation of phosphorylated tau protein followed by the formation of NFTs [96]

Meanwhile, the RMSD results for the protein reflected minor fluctuations (0.80 1.60) during the 100ns trajectory
