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This disruption impedes NLRP3 oligomerization and the subsequent formation of downstream ASC speckles, thereby ultimately obstructing inflammasome assembly and activation [385]
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The results came from a sub-analysis of the REDEFINE-1 trial and showed that cagrilintide led to significant weight loss in adults with overweight or obesity that did not have diabetes
10.1016/j.jpsychires.2019.01.016 83 ChurchJ
