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Dyslipidemia, hyperglycemia, along with other metabolic disorders, results in IR and/or islet cell dysfunction via some shared pathways, such as inflammation, endoplasmic reticulum stress (ERS), oxidative stress, and ectopic lipid deposition

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Melatonin synthesized in the pineal gland is rapidly and pulsatilely released into the bloodstream and cerebrospinal fluid, from where it is distributed to organs and tissues throughout the body. MELATONIN RECEPTORS Activation of melatonin receptors determines the subsequent biological effects
