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The answer is about coverage and contact time

Aliabadi, H

Wortel IMN, van der Meer LT, Kilberg MS, van Leeuwen FN (2017) Surviving stress: modulation of ATF4-mediated stress responses in normal and malignant cells

2.2.4 A circRNA that upregulates cofilin-2 Circ-PSEN1, also known as circ_0008521, regulates ferroptosis in retinal pigment epithelial cells of patients with diabetic retinopathy (DR) via the miR-200b-3p/cofilin-2 (CFL2) axis (Zhu et al., 2021a)