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Harvard University epidemiologist Walter Willett says Ames is "obviously playing a roleand somebody in science has to do itwhere sometimes you need to state things provocatively to stir up the pot and get people to look critically at issues they weren't looking at before." As Ames neared 65, his thoughts turned to the notion of aging

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Gut colonization with methanogenic archaea reduced plasma TMAO levels and attenuated the burden of AS, with decreased area and fat content in the atherosclerotic plaques, in Apo E / mice fed a TMA-supplemented or high choline diet (Ramezani et al., 2018)