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Hemin suppresses the TSS pathway CBS expression and interferes with de novo cysteine biosynthesis and GSH generation, leading to elevated oxidative stress

Citations Citations to this article as recorded by Cancer-associated fibroblasts as a potential therapeutic target for thyroid cancers Kashmira Chakraborty, Ramya Lakshmi Rajendran, Shristy Kothiwal, Sourav Majhi, Anuvab Dey, Subhrojyoti Ghosh, Ankita Chowdhury, Chandrajeet Dhara, Rijula Batabyal, Sreyee Biswas, Chae Moon Hong, Prakash Gangadaran, Byeong-Cheol Ahn International Journal of Surgery.2026

As those toxic metals react with and deplete cellular GSH 33,34 , this transcriptional response provides additional evidence that acivicin restricts the import of GSH precursors 31