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A previous in vitro study immersed the rat tail tendon in AGEs and found that the tendon texture became stiff and rigid, and the color of the Achilles tendon was changed from pearl white to gray-yellow or gray-white [42]

Drug Interactions Several common medications reduce B12 absorption: Metformin (diabetes) significant reduction in B12 absorption Proton pump inhibitors (Omeprazole, Pantoprazole) reduce stomach acid needed for absorption H2 blockers (Ranitidine, Famotidine) similar effect to PPIs Colchicine (gout) may reduce B12 absorption If you take any of these medications long-term, B12 supplementation is strongly recommended

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