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Interestingly, the molecular clock has been revealed to regulate Nrf2 levels and activity also in innate immune cells

Notably, elevated levels of ascorbate were found in diurnal animals compared to nocturnal species, indicative of a protective role against UV radiation [27]

Several FDA-approved anti-cancer drugs, including sorafenib, can induce ferroptosis by inhibiting SLC7A11 activity, even though they also elicit apoptosis in preclinical studies [195]
