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It has also been demonstrated that the long non-coding RNA PWAR6, which is overexpressed in metastatic colorectal cancer tissues, functions as a competitive inhibitor of Keap1, thereby promoting the stabilization of NRF2
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This overload promotes mitochondrial imbalance and reactive oxygen species generation, leading to oxidative stress (OS), which contributes to chronic degenerative diseases (Reference Packard, Boren and Taskinen4)
in Front Immunol (2023) Vol.14 pp1133394 Editorial: Insights in cytokines and soluble mediators in immunity: 2022 Melgrati, S
