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The relatively stable size of the overall lesion can be explained by the fact that their slow rate of proliferation is offset by cell-attritional factors such as immunosurveillance

Non-restorative sleep with prolonged latency, longer awake time after sleep onset, reduced sleep efficiency, decreased stage 2 sleep, more Stage 3, and longer rapid eye movement sleep latency [164] is frequent in ME/CFS and contributes significantly to CD as well as impaired mood

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It is made from two amino acids: lysine and methionine