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For example, if an effect has given Bear Cub, a 2/2 creature, -4/-0 so that it's a -2/2 creature, doubling its power and toughness gives it -2/+2, and it becomes a -4/4 creature

Number 48 Language English Legal Formats Commander, Legacy, Modern, Vintage Not Legal Formats Alchemy, Brawl, Competitive Brawl, Historic, Pauper, Pioneer, Standard, Timeless Rulings (10/1/2005) The ability triggers when a player casts an instant or sorcery *card*

[c]Yorion, Sky Nomad[/c] sees competitive play in a multitude of formats, in part due to its more forgiving deckbuilding restriction

Theres no way to discard a creature card with madness, cast it, and sacrifice it to pay for both of Ruthless Disposals additional costs