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Plus, think about it

To the extent that the past is prologue, the history of drug use provides a sobering lesson: Drug use has been common since ancient times and has been common in almost every society

Microglia as Therapeutic Target for the Treatment of Nicotine Addiction We speculate that neurodevelopmental changes may be modulated by pharmacotherapy targeted to activate change in microglial phenotype which may promote brain homeostasis and a neuro-adaptation that favors decreased dependence on nicotine thus microglia are a promising therapeutic target that need to be explored