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Electronic Cigarettes, Hemodynamic Changes, and Arterial Stiffness Combustible tobacco product consumption is a well-known contributor to a wide range of side effects impacting overall cardiac hemodynamics, including elevations in heart rate [68], blood pressure [69], and changes in arterial stiffness [70], all associated with cardiovascular disease development including hypertension, myocardial infarction, aortic aneurysm, atherosclerosis, stroke, or even greater mortality [71]