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Nicotine in cigarettes decrease oxygen to the heart, increases blood pressure, blood clots, and damages coronary arteries
Besides the induction of inflammatory macrophages, nicotine treatments promote the M2 polarization, reduces the secretion of several proinflammatory cytokines in macrophages, and suppresses the alveolar macrophages to present the inhaled antigen to lymphocytes [130, 131]
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