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The FDA's February 1, 2008 "safety alert" states that symptoms seen in Chantix users include "changes in behavior, agitation, depressed mood, suicidal ideation, and attempted and completed suicide." Should the FDA permit Pfizer to continue to sell Chantix if reports ofscores of suicides are attributable to it and Chantix's long-term benefit as a stand-alone quitting aid is likely slightly less than quitting without it

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(2022, May 24)

That study concluded that smoking cessation was associated with weight gain, ranging from 1 to 10 kg or 0.1 to 0.2 increment in BMI during the evaluation period of six years, but the benefits of smoking cessation outweighed the risks and reduced mortality in the general population