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These findings suggest that cutaneous vasculature is not merely a passive route for immune cell trafficking but also serves as an active amplifier of pruritic signaling ( 3 Bidirectional crosstalk between MCs and intraepidermal nerve fibers The bidirectional communication between mast cells and sensory neurons and their signaling pathways are illustrated in Figure 2

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h p value: calculated using MannWhitney U (M-W) test and KruskalWallis H (K-W) test