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In this analogy, EGFR ligands are like fuel, allowing cancer cells, in the absence of PI3K, to power their growth and survival through the engine of EGFR instead

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For each exposure and outcome examined, an algorithm was identified as resulting in differential misclassification when its sensitivity and/or specificity differed between at least two levels of the exposure or outcome variables, as indicated by non-overlapping 95% confidence intervals [22]

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