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The most common consumption of smokeless tobacco includes chewing tobacco (Africa, Asia, and North America), and both moist snuff (Asia, Middle East, North America, and South Africa) and dry snuff (Brazil, Europe, South and Central Asia, Nigeria, South Africa, and North America) (Asma et al

It is considered to be a carcinogenic chemical that can cause certain blood cancers

Hepatitis C virus core protein overcomes H2O2-induced apoptosis by downregulating p14 expression via DNA methylation

Additionally, the associated accumulation of UVR-induced mutp53 in early phases of skin carcinogenesis in NMSC suggests that preventing its formation could be a promising strategy for SC prevention