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When they looked at the brains of the mice under a microscope, they found a possible reason: Just two hours after they'd been dosed with cocaine, new connections had sprouted between brain cells in the frontal cortex

The main idea is to reduce nicotine content over a period of time resulting in a lower intake of nicotine, a lower level of nicotine dependence and to collectively find a dosage level in which cigarettes do not produce any reinforcing effects

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Nicotinic StomatitisIn nicotinic stomatitis, the hard palate (roof of the mouth) appears white instead of pink, and numerous, small raised areas with red centers are found throughout the palate (see Left)