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The trend towards higher G-CSF levels that we observed in smokers has been reported previously 37 and is of potential import since the administration of this cytokine to humans has been shown to increase both granulocytes and monocytes 38 and thus may be at least partially responsible for the increase we see in these white blood cells in smokers

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One difference the scientists noted between humans and mice models of this experiment is that once the cigarette smoke exposure ceases in mice, the inflammation tends to die down but in human cases, it does not