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Complement activation, smoking, inflammatory mucosal and macular degeneration diseases) As indicated before, the activation of the complement system is a significant factor in the development and exacerbation of inflammation ( in vitro experiments demonstrated that exposure of human respiratory epithelial cells to cigarette smoke extract resulted in complement activation, as evidenced by increased levels of complement activation fragments (C4a, C3a, and C5a) and immunofluorescent staining for C3d ( in vivo study using complement-deficient ( C 3 - / - ) mice exposed to cigarette smoke showed a significant reduction in nasal damage

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