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While early reports have also described a connection between acute e-cigarette use and biomarkers linked to elevated cancer risk, there is limited evidence at this point to suggest a direct causal association between ENDS usage and cancer development [144]

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However, animals studies found that hypothalamic neuropeptide Y (NPY), a potent orexigenic neuropeptide that increases food intake, may be enhanced (either acutely [56] or after 7 weeks of nicotine exposure [57]) or, conversely, suppressed after 12 weeks of exposure [58]
