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The aerosols that e-cigarette users breathe in from the device and exhale contain harmful substances and particles, including: Diacetyl, a flavoring that has been linked to a serious lung disease called popcorn lung Ultrafine particles that may be inhaled deep into the lungs Volatile organic compounds Cancer-causing chemicals Heavy metals, such as nickel, tin, and lead Vapors from e-cigarettes are toxic to the persons lungs, causing acute lung injury, irreversible lung damage, and can lead to lung cancer and asthma, said Warren

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However, two studies have suggested that tobacco smoke directly inhibits the function of ILC2s, thereby affecting the pathogenesis of two respiratory diseases, namely, asthma and COPD