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Inflamm Bowel Dis

Nicotine content of electronic cigarettes, its release in vapour and its consistency across batches: regulatory implications

However, as a NAD-dependent deacetylase that modulates apoptosis of hepatocytes in response to oxidative and genotoxic stress, SIRT1 inactivation could provoke insulin resistance and pro-inflammatory cytokine (TNF-, IL-1, and IL-6) expression and pro-inflammatory signaling pathway (STAT3 and JNK) activation 135 , all of which are important factors governing hepatoma cells transformation