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All funding had no role in study design, data analysis, paper submission and publication

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Nomenclature AD Alzheimers disease ABC ATP-binding cassette A amyloid- ARTs antiretroviral therapies BBB blood-brain barrier CNS central nervous system DAT dopamine transporter DMTs disease-modifying treatments E-cig electronic cigarette HIF-1 hypoxia-inducible factor-1 MATE 1 multidrug and toxin extrusion protein-1 MPP+ 1-methyl-4-phenylpyridinium MS multiple sclerosis nAchRs nicotinic acetylcholine receptors NET norepinephrine transporter NKCC Na + -K + -2Cl co-transporter OCTs organic cation transporters OCTn organic cation/carnitine transporters PD Parkinsons disease PMAT plasma monoamine transporters r-tPA tissue plasminogen activator PI3K phosphoinositide-3 kinase PKC protein kinase C SERT serotonin transporter SLC solute carrier transporters TEA tetraethylammonium TS tobacco smoke/tobacco smoking TJ tight junction US-FDA US food and drug administration References 1 AbbottN