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DNA methylation aberrations are also more easily induced in males than females by early environments, such as prenatal exposure to cigarette smoke or a lack of folate ( Taken together, DNA methylation at any given CpG is the result of multiple processes that are orchestrated as a developmental cascade involving, first, global demethylation after fertilization, then, cell/tissue-specific re-methylation during very early embryogenesis and, finally, maintenance of DNA methylation throughout the remainder of life

Led by frontman Greg Gonzalez, Cigarettes After Sex includes Randall Miller (bass), Jacob Tomsky (drums), and Josh Marcus (keyboards)