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Stage Four: Pre-Cancerous Lesions DNA mutations result in the appearance of visible lesions in the mouth's lining: Leukoplakia: White spots that cannot be removed Erythroplakia: Red patches (high risk for developing cancer) Oral Submucous Fibrosis (OSMF): Increasing stiffness of the mouth with difficulty opening Step 5: Cancerous Change After years of repeated exposure, genetic changes result in cancer that will then grow and spread into adjacent tissues until ultimately reaching the lymph nodes in the neck and even other organs

We derived the odds ratio (OR) from these tables computed as follows: The interpretation of the odds ratio is as follows: if the OR is higher than 1, age-DEGs and smoking-DEGs overlap more often than expected if the two variables were independent

Totowa, NJ: Springer

After just one month, the mice showed changes in markers of health in the blood serum, liver and brain tissues