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As sensation seeking has long been implicated in the reinforcing effects of psychostimulants 52 , we thus proposed a reinforcement loop underlying the maintenance of smoking, where smoking behaviour could reduce GMV in the right vmPFC, leading to disinhibited reward-seeking behaviour (i.e., higher sensation seeking), and hence, in turn, promote future smoking behaviour
This is because freebase nicotine provides a stronger sensation in the throat compared to nic salts
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