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720 mg once every 2 months (FDA) Patients taking 960 mg as maintenance dose, with a strong CYP3A4 inhibitors: 720 mg once every 2 months (Health Canada and FDA) Patients taking 960 mg as maintenance dose, with a strong CYP 2D6 AND CYP3A4 inhibitors: Avoid use (Health Canada and FDA) Patients taking 960 mg as maintenance dose, with a strong CYP3A4 inducers: Avoid use (Health Canada and FDA) Time of Day Not applicable Food Not applicable Cigarettes Smoking has no effect on aripiprazole metabolism Adverse effects Agitation Anxiety Insomnia Akathisia Other Warnings Class Warning: Increased Mortality in Elderly Patients with Dementia Elderly patients with dementia treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo