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High doses of nicotine may cause tachycardia, high blood pressure, seizures, coma, and death

But if you also include non-fatal health effects, then although tobaccos still worse in high-income countries, alcohol causes more of a worldwide health problem

Research has shown that harmful chemicals leached from discarded butts, which include nicotine, arsenic and heavy metals, can be acutely toxic to aquatic organisms. A 2011 study by San Diego State University suggested that the chemicals leached from one smoked cigarette butt were capable of killing half of the fish present in a one-litre bucket of water, while researchers at the UKs Anglia Ruskin University found cigarette butts significantly hindered the growth of terrestrial plants

"Comprehensive organic emission profiles, secondary organic aerosol production potential, and OH reactivity of domestic fuel combustion in Delhi, India"