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Conclusion: An Estimate, Not an Exact Science In summary, while its impossible to give a single, universally accurate number, current understanding suggests that for common nicotine salt-based disposable vapes and pod systems, approximately 10-15 puffs of a 5% (50mg/ml) nicotine e-liquid or 15-25 puffs of a 2% (20mg/ml) nicotine e-liquid might deliver a roughly comparable amount of absorbed nicotine to one traditional cigarette