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Authors concluded that combining NRT with behaviour change counselling resulted in a significantly higher quit rates and lower cotinine levels, but significant impact on patient-related or microbiological outcomes were not detected (Sharma et al., 2018)

In recent years, smoking has increasingly been seen as an environmental health threat, producing indoor air pollution that has been shown to cause adverse health effects in nonsmokers

In addition, the irritant responses to TS stimulation were proposed to be mediated by vagal bronchopulmonary C-fibres and RARs (Lee et al., 1993)