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Food and Drug Administration (FDA) or was on the market before August 8, 2016, and had a Premarket Tobacco Product Application (PMTA) submitted to the FDA by September 9, 2020, which remains under active review or has an MDO that is stayed

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While they lack tobacco leaf content, they still pose risks to oral health, including gum irritation and potential dependence. Chemical Composition and Oral Health Implications Smokeless tobacco products contain a complex mixture of chemicals, including: Nicotine : An addictive substance that constricts blood vessels, reducing blood flow to the gums and impairing healing. Tobacco-specific nitrosamines (TSNAs) : Potent carcinogens linked to oral and other cancers. Sugars and flavorings : Added to enhance taste but contribute to tooth decay