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Second, while changes in plasma MG concentrations were not predictive of DEQ items that are reflective of acute effects from nicotine (e.g., stimulated and good drug effects ), they were predictive of cooling effect , a typical subjective effect of menthol, but only in menthol smokers in the absence of concurrent active nicotine infusion (i.e., in the placebo condition)

2024 (QHP Detailed Enrollment Tab, Sum of Column Q)

In its statement to the Bureau, PMI acknowledged that adult smokers switching to Iqos obtain comparable amounts of nicotine to that from cigarettes