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Gene expression and histological studies of the airway epithelium have demonstrated that both molecular dysfunction and cellular imbalance due to shifting cell composition in the epithelium are common features of most chronic lung diseases, including asthma 3 and chronic obstructive pulmonary disease 4 (COPD)

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Saddle stems, on the other hand, feature a flat base that sits flush against the shank before curving upwards towards the mouthpiece