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The expression of p53 is observed in the spermatogonium stage, peaks in primary spermatocytes, and slightly decreases in the sperm stage, which is consistent with DNA damage and recombination repair in the meiotic process ( Tp53 knockout mice prior to synapsis leads to increased spermatocyte death and testis atrophy ( Previous studies have shown that the level of p53 is the key factor that determines whether a cell undergoes growth arrest or apoptosis

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