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You should consider a fertility evaluation if: You have been trying to conceive without success You smoke regularly and are concerned about fertility Your semen analysis shows abnormal sperm parameters You are planning IVF or ICSI treatment Early fertility assessment can help identify the cause and improve treatment planning

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(1) In-vitro models of mesenchymal cells are developed by culturing fibroblast/myofibroblast in three-dimensional collagen gels which shows their ability to contract (8,11)