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Additionally, when the e-liquid heats up, more toxic chemicals are formed

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For the analysis of varenicline as a pharmacotherapy option for smoking cessation in smokers with heart disease, four publications (three RCTs) selected from a previous systematic review and through updated search were included for synthesis.43, 53, 468, 469 The results showed that among smokers with cardiovascular disease, varenicline significantly increased smoking cessation rates at six months or longer compared to placebo (RR, 2.35