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Additionally, the drug label includes a boxed warning related to a potential risk of thyroid tumors

Food and Drug Administration (FDA) for its liraglutide injection (18 mg/3 mL)
Notably, a seven-day regimen of intraperitoneal administration of the GLP-1 analog Exendin-4 has been observed to attenuate anxiety-like behaviors in mice undergoing heroin withdrawal

There has been considerable interest in the development of nonpeptidic ligands for GLP-1R as leads with improved bioavailability (Chen et al., 2007
