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However, individual genetic variations mean some people experience joint-related discomfort during semaglutide use for reasons beyond the drug's primary mechanism

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Gastrointestinal side effects are the most common and include: Nausea (reported in 12% to 29% of patients, depending on dose) Diarrhea (occurring in 13% to 23% of patients) Vomiting (affecting 4% to 9% of patients) Constipation (reported in 6% to 11% of patients) Abdominal pain and dyspepsia (affecting 6% to 9% of patients) Decreased appetite (common and often contributes to weight loss) These gastrointestinal symptoms typically occur during dose escalation and often improve with continued use