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doi:10.2174/1573399816666200705210006 2
Anxiety and inexperience with self-injection, unrealistic expectations, and side-effects can reduce adherence and lead to discontinuation of treatment

Analyzing the FDA Adverse Event Reporting System showed sitagliptin to be the drug reported to cause the most hypoglycemia, whereas the hypoglycemic potential of the meglitinides (short-acting sulfonylurea analogs) was not picked up as significant and the hypoglycemic potential of sulfonylureas and even of insulin was greatly underestimated when these results are compared with well-known epidemiological data (Supplementary Fig

The Cochrane Database of Systematic Reviews, 12 (12), CD008650