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Another study demonstrated that empagliflozin appears to primarily reduce oxidative stress in cardiomyocytes by inhibiting NHE1, consequently enhancing cardiomyocyte stiffness, promoting extracellular matrix remodelling, mitigating centripetal hypertrophy of the heart, and alleviating systemic inflammation [119]

The FDA had also referred BPI Labs to the Florida Board of Pharmacy in 2021