glp-1 agonist. Frontiers Evolution of GLP‐1 Receptor Agonists
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10.7717/peerj.11128 92 SinghA.FernandesJ.ChhabraG.KrishnaA.BanerjeeA
Studies show that single-molecule dual GIPR/GLP-1R agonists have better insulinotropic and antihyperglycemic effects than GLP-1 agonists in rodents, primates, and humans, without causing gastrointestinal disturbances [58]
Studies have demonstrated that liraglutide significantly impairs colorectal cancer cell migration, invasion, and proliferation by inhibiting the PI3K/Akt/mTOR signaling pathway, while concurrently promoting tumor cell apoptosis [77]
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