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FLOW Trial: In T2DM patients with chronic kidney disease (CKD), semaglutide reduced the composite of kidney-disease progression or HF events by 27% (HR 0.73, 95% CI 0.540.98) alongside renal benefits [58]

Some researchers have also voiced concern that a 25 to 30 percent reduction in body weight could compromise some patients health, perhaps by leading to nutritional deficiencies or loss of muscle mass

By slowing digestion, reducing hunger, and improving insulin sensitivity, GLP-1 treatments make it easier for patients to adopt healthier eating patterns and sustain them long-term

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