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Compared with GLP-1 RAs, more participants receiving tirzepatide 15 mg discontinued treatment due to adverse events (OR 2.29 [95% CI 1.39, 3.75], I 2 0%), whereas no difference was evident for tirzepatide 5 mg and 10 mg (ESM Table 3)

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Tobacco Use Disorder Outcomes Wang, Volkow, and colleagues also conducted a study of 222,942 individuals with tobacco use disorder and type 2 diabetes, with findings showing individuals prescribed semaglutide showed a 32% lower risk of tobacco-related healthcare visits and were less likely to need smoking cessation medications or counseling during the 12-month follow-up period, with the most notable effects appearing within the first 30 days (Wang et al., 2024c)

Much evidence suggests that activation of anorexogenic proopiomelanocortin (POMC) neurons and simultaneous inhibition of orexigenic neuropeptide Y/Agouti-related peptide (NPY/AgRP) neurons in the ARC appears to be one of the major mechanisms for GLP-1R mediated inhibition of food intake