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ACE inhibitor (ACE-I)-induced angioedema, with an underreported incidence of 0.10.7%, manifests as non-pitting oedema of subcutaneous and submucosal tissues

Investigational Uses Research is ongoing in: Chronic kidney disease (CKD)[6] Heart failure with preserved ejection fraction (HFpEF)[6][1] Cardiovascular outcomes in obesity[6] Preliminary HFpEF results suggest a 38% reduction in major complications vs placebo[1]