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While additional research is needed to determine how GLP-1 RAs put a person at an increased risk for NAION, it may be linked to fluctuations in blood pressure and blood sugar, diabetes-related vascular issues, and low blood sugar (hypoglycemia) caused by Mounjaro

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Activation of GIP receptors enhances glucose-dependent insulin secretion and improves insulin sensitivity, while GLP-1 receptor stimulation promotes insulin release, suppresses glucagon secretion, and slows gastric emptying
