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155 However, whether this can be extrapolated to other CMRFs, and whether there is a pharmacoeconomic imperative, needs further clarification

The Diabetes Control and Complications Trial and its long-term follow up, the Epidemiology of Diabetes and its Complications study, demonstrated that stringent glycemic control with intensive insulin therapy can prevent or postpone progression of microvascular disease and reduce the risk for macrovascular disease and all-cause mortality

Interventions for treating children and adolescents with overweight and obesity: an overview of Cochrane reviews