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A study (Benedict et al., 2024) shows that between 2006 and 2021, 911.000 patients received AA oncology drugs
Further supporting melatonins potential impact on brain insulin, a rat study demonstrated that melatonin, upon binding to its membrane-bound receptors, can initiate intracellular pathways in the brain typically activated by insulin binding to the insulin receptor (e.g., AKT serine phosphorylation) [137]
This section delves into strategies aimed at mitigating these risks, ensuring patient safety, and maintaining therapeutic efficacy
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