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Small, frequent meals rather than large portions can help manage nausea whilst ensuring adequate caloric intake

Side Effects and Safety Retatrutide's side effects are generally consistent with other GLP-1 receptor agonists, most commonly including mild to moderate gastrointestinal issues like nausea, vomiting, diarrhea, and constipation

Animal and mechanistic data suggest it may have weak estrogenic effects, potentially counteracting enclomiphene's receptor-blocking action at the hypothalamus

Physiological changes may depend on degree of left to right shunt, number of veins involved, their sites of connection and associated lesions